货号	规格	价格	上海	北京	珠海	重庆	武汉
S81119-5mg买3赠1	98.50%	￥600.00 S81119-5mg ￥600.00 现货（买3赠1）	3 3	-	-	-	-
S81119-10mg买3赠1	≥98%	￥970.00 S81119-10mg ￥970.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S81119-50mg	98.50%	￥3000.00 S81119-50mg ￥3000.00 现货	1 1	-	-	-	-
S81119-100mg	≥98%	￥5000.00 S81119-100mg ￥5000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively.

靶点：

Aurora A:21 nM (IC50);Aurora B:15 nM (IC50);JAK; CDK; Src; AuroraKinase

体外研究：

TAK-901 exhibits time-dependent, tight-binding inhibition of Aurora B, but not Aurora A. Consistent with Aurora B inhibition, TAK-901 suppresses cellular histone H3 phosphorylation and induces polyploidy. In various human cancer cell lines, TAK-901inhibits cell proliferation with effective concentration values from 40 to 500 nM. Examination of a broad panel of kinases in biochemical assays reveals inhibition of multiple kinases. However, TAK-901 potently inhibits only a few kinases other than Aurora B in intact cells, including FLT3 and FGFR2.

体内研究：

In rodent xenografts, TAK-901 exhibits potent activity against multiple human solid tumor types, and complete regression is observed in the ovarian cancer A2780 model. TAK-901 also displayed potent activity against several leukemia models. TAK-901 induces pharmacodynamic responses consistent with Aurora B inhibition and correlating with retention of TAK-901 in tumor tissue.

参考文献：

1. Farrell P, Shi L, Matuszkiewicz J, Balakrishna D, Hoshino T, Zhang L, Elliott S, Fabrey R, Lee B, Halkowycz P, Sang B, Ishino S, Nomura T, Teratani M, Ohta Y, Grimshaw C, Paraselli B, Satou T, de Jong R. Biological characterization of TAK-901, an investigational, novel, multitargeted Aurora B kinase inhibitor. Mol Cancer Ther. 2013 Apr;12(4):460-70.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.982 ml	9.908 ml	19.815 ml
5 mM	0.396 ml	1.982 ml	3.963 ml
10 mM	0.198 ml	0.991 ml	1.982 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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TAK-901

5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)