| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81124-1mg买3赠1 |
96.40% | ￥210.00 |
8 | - | - | - | - |
|
S81124-2mg买3赠1 |
96.40% | ￥340.00 |
8 | - | - | - | - |
|
S81124-5mg买3赠1 |
96.40% | ￥520.00 |
8 | - | - | - | - |
|
S81124-10mg买3赠1 |
96.40% | ￥900.00 |
6 | - | - | - | - |
|
S81124-25mg买3赠1 |
96.40% | ￥1400.00 |
5 | - | - | - | - |
|
S81124-50mg买3赠1 |
≥96% | ￥2020.00 |
货期：2-3天 | - | - | - | - |
|
S81124-100mg买3赠1 |
≥96% | ￥3630.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | JAK2：6 nM (IC50)；JAK3：169 nM (IC50)；RET：17 nM (IC50)；FLT3：25 nM (IC50);Apoptosis; FLT; c-RET; JAK; Autophagy | ||||||||||||||||||||
| 体内研究： | TG101209 (100 mg/kg) effectively prolongs the survival in JAK2V617F-induced disease (10 days). Compared with placebo-treated animals, TG101209-treated animals exhibit statistically significant, dose-dependent reduction in the circulating tumor cell burden at day +11 to 20% | ||||||||||||||||||||
| 参考文献： | 1. Pardanani A, et al. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia. 2007 Aug;21(8):1658-68. 2. Ma AC, et al. A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Exp Hematol. 2009 Dec;37(12):1379-1386.e4. 3. Sun Y, et al. Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models. J Thorac Oncol. 2011 Apr;6(4):699-706 4. Cuesta-Dominguez A, et al. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PLoS One. 2012;7(2):e3245 | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 50 mg/mL (98.10 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
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营业执照(三证合一)
北京