| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81131-1mg买3赠1 |
99.00% | ￥190.00 |
3 | - | - | - | - |
|
S81131-2mg买3赠1 |
99.00% | ￥256.00 |
5 | - | - | - | - |
|
S81131-5mg买3赠1 |
99.00% | ￥400.00 |
4 | - | - | - | - |
|
S81131-10mg买3赠1 |
99.00% | ￥630.00 |
1 | - | - | - | - |
|
S81131-25mg买3赠1 |
99.00% | ￥1120.00 |
4 | - | - | - | - |
|
S81131-50mg买3赠1 |
≥99% | ￥1500.00 |
货期：2-3天 | - | - | - | - |
|
S81131-100mg买3赠1 |
≥99% | ￥2700.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | HER2;EGFR; HER | ||||||||||||||||||||
| 体内研究： | Tucatinib (ONT-380, 200 mg/kg/d) shows a survival benefit when each drug is dosed at the maximum-tolerated dose. Tucatinib and its active metabolite causes a significant reduction in brain pErbB2 (80%). Tucatinib (ARRY-380) demonstrates significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size) at the higher dose level in 9/12 animals. Tucatinib (50 mg/kg/d) in combination with trastuzumab shows a 98% TGI with complete regressions in 9/12 animals and two partial regressions. | ||||||||||||||||||||
| 参考文献： | 1. Moulder-Thompson S, et al. Phase 1 Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+ Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC). Clin Cancer Res. 2017 Jan 4. pii: clincanres.1496.2016. 2. Abstract: In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 852. doi:1538-7445.AM2012-852 3. P. Lee, et al. In Vivo Activity of ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2 in Combination with RP-56976. Cancer Research | ||||||||||||||||||||
| 溶解性： | DMSO : 41.67 mg/mL (86.72 mM; ultrasonic and warming and heat to 60°C) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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