| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81146-5mg促销 |
≥98% | ￥660.00 ￥390.00 |
5 | - | - | - | - |
|
S81146-10mg促销 |
≥98% | ￥1030.00 ￥710.00 |
5 | - | - | - | - |
|
S81146-25mg促销 |
≥98% | ￥2060.00 ￥1270.00 |
3 | - | - | - | - |
|
S81146-50mg促销 |
≥98% | ￥3090.00 ￥2070.00 |
4 | - | - | - | - |
|
S81146-100mg促销 |
≥98% | ￥5560.00 ￥3190.00 |
2 | - | - | - | - |
|
| 产品描述： | GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A. | ||||||||||||||||||||
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| 靶点： | Aurora B:0.38 nM (Ki);Aurora C:1.5 nM (Ki);Apoptosis; Tie-2; FLT; AMPK; AuroraKinase | ||||||||||||||||||||
| 体内研究： | In nude mice implanted with human colon tumor (HCT116) xenografts, a single dose of GSK-1070916 administered i.p. inhibits HH3-S10 phosphorylation in a dose-dependent manner. Repeated i.p. administration of GSK-1070916 produces complete or partial antitumor activity in 4 of 8 tumor types [lung, A549; colon, HCT116; acute myelogenous leukemia (AML), HL60; and chronic myelogenous leukemia, K562], stable disease in 3 of 8 (colon, Colo205; lung, H460; and breast, MCF-7), and tumor growth delay in 1 of 8 tumor types (colon, SW620). Daily administration of GSK-1070916 is generally well-tolerated | ||||||||||||||||||||
| 参考文献： | 1. Adams ND, et al. Discovery of GSK-1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. 2. Hardwicke MA, et al. GSK-1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Mol Cancer Ther. 2009 Jul;8(7):1808-17. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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