首页
订购/客服:400-666-5481

GSK1070916

    
≥98%

GSK1070916

源叶(MedMol)
S81146 一键复制产品信息
942918-07-2
C30H33N7O
507.63
3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S81146-5mg促销
≥98%

¥660.00 ¥390.00

5 - - - -
S81146-10mg促销
≥98%

¥1030.00 ¥710.00

5 - - - -
S81146-25mg促销
≥98%

¥2060.00 ¥1270.00

3 - - - -
S81146-50mg促销
≥98%

¥3090.00 ¥2070.00

4 - - - -
S81146-100mg促销
≥98%

¥5560.00 ¥3190.00

2 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A.
靶点: Aurora B:0.38 nM (Ki);Aurora C:1.5 nM (Ki);Apoptosis; Tie-2; FLT; AMPK; AuroraKinase
体内研究: In nude mice implanted with human colon tumor (HCT116) xenografts, a single dose of GSK-1070916 administered i.p. inhibits HH3-S10 phosphorylation in a dose-dependent manner. Repeated i.p. administration of GSK-1070916 produces complete or partial antitumor activity in 4 of 8 tumor types [lung, A549; colon, HCT116; acute myelogenous leukemia (AML), HL60; and chronic myelogenous leukemia, K562], stable disease in 3 of 8 (colon, Colo205; lung, H460; and breast, MCF-7), and tumor growth delay in 1 of 8 tumor types (colon, SW620). Daily administration of GSK-1070916 is generally well-tolerated
参考文献: 1. Adams ND, et al. Discovery of GSK-1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. 2. Hardwicke MA, et al. GSK-1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Mol Cancer Ther. 2009 Jul;8(7):1808-17.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.97 ml 9.85 ml 19.699 ml
5 mM 0.394 ml 1.97 ml 3.94 ml
10 mM 0.197 ml 0.985 ml 1.97 ml
50 mM 0.039 ml 0.197 ml 0.394 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:JS298415 货号:S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×