| 产品描述： | CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively. |
| 靶点： |
Aurora A:42 nM (IC50);Aurora B:198 nM (IC50);Aurora C:227 nM (IC50);AuroraKinase |
| 体内研究： |
Growth of HCT116 xenografts in nude mice is inhibited after i.p. administration of CCT129202. p21, the cyclin-dependent kinase inhibitor, is induced by CCT129202. Up-regulation of p21 by CCT129202 in HCT116 cells led to Rb hypophosphorylation and E2F inhibition, contributing to a decrease in thymidine kinase 1 transcription |
| 参考文献： |
1. Chan F, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-20°C |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.012 ml |
10.06 ml |
20.12 ml |
| 5 mM |
0.402 ml |
2.012 ml |
4.024 ml |
| 10 mM |
0.201 ml |
1.006 ml |
2.012 ml |
| 50 mM |
0.04 ml |
0.201 ml |
0.402 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京