| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81150-1mg促销 |
99.20% | ￥128.00 ￥102.00 |
4 | - | - | - | - |
|
S81150-2mg促销 |
99.20% | ￥190.00 ￥152.00 |
5 | - | - | - | - |
|
S81150-5mg促销 |
99.20% | ￥285.00 ￥228.00 |
5 | - | - | - | - |
|
S81150-10mg促销 |
99.20% | ￥460.00 ￥414.00 |
5 | - | - | - | - |
|
S81150-25mg |
99.20% | ￥840.00 |
3 | - | - | - | - |
|
S81150-50mg |
≥99% | ￥1360.00 |
货期：2-3天 | - | - | - | - |
|
S81150-100mg |
≥99% | ￥2390.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. | ||||||||||||||||||||
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| 靶点： | c-Met/HGFR | ||||||||||||||||||||
| 体内研究： | In mice bearing established GTL16 xenografts, JNJ-38877605 (40 mg/kg/day, p.o., total 3day) results in a statistically marked decrease in the plasma levels of human IL-8 (0.150-0.050 ng/mL) and GROα (0.080-0.030 ng/mL). While concentrations of uPAR in the blood become reduced to more than 50% at the same dose. | ||||||||||||||||||||
| 动物实验： | Animal Models: GTL16 cells are inoculated subcutaneously into the right posterior flank (or both right and left posterior flanks,for determination of uPAR and IL-6) of 6-week-old immuno-deficient nu/nu female mice on Swiss CD1 background. Formulation: JNJ-38877605 is dissolved in PBS. Dosages: ≤40 mg/kg/day. Administration: Administered via p.o. | ||||||||||||||||||||
| 参考文献： | 1.De Bacco F, et al. J Natl Cancer Inst. 2011 Apr, 103(8), 645-661. 2.Torti D, et al. Int J Cancer. 2012, 130(6), 1357-1366. | ||||||||||||||||||||
| 溶解性： | H2O:<1 mg/mL Ethanol:<1 mg/mL DMSO:35 mg/mL (92.8 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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