货号	规格	价格	上海	北京	武汉	南京
S81150-1mg	99.2%	￥216.00 S81150-1mg ￥216.00 现货	5 5	-	-	-
S81150-2mg	99.2%	￥384.00 S81150-2mg ￥384.00 现货	5 5	-	-	-
S81150-5mg	99.2%	￥440.00 S81150-5mg ￥440.00 现货	5 5	-	-	-
S81150-10mg	99.2%	￥720.00 S81150-10mg ￥720.00 现货	5 5	-	-	-
S81150-25mg	99.2%	￥1440.00 S81150-25mg ￥1440.00 现货	4 4	-	-	-
S81150-50mg	≥99%	￥2160.00 S81150-50mg ￥2160.00 2-3天	0 货期：2-3天	-	-	-
S81150-100mg	≥99%	￥3920.00 S81150-100mg ￥3920.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

产品描述：

JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

靶点：

c-Met/HGFR

体内研究：

In mice bearing established GTL16 xenografts, JNJ-38877605 (40 mg/kg/day, p.o., total 3day) results in a statistically marked decrease in the plasma levels of human IL-8 (0.150-0.050 ng/mL) and GROα (0.080-0.030 ng/mL). While concentrations of uPAR in the blood become reduced to more than 50% at the same dose.

动物实验：

Animal Models: GTL16 cells are inoculated subcutaneously into the right posterior flank (or both right and left posterior flanks,for determination of uPAR and IL-6) of 6-week-old immuno-deficient nu/nu female mice on Swiss CD1 background. Formulation: JNJ-38877605 is dissolved in PBS. Dosages: ≤40 mg/kg/day. Administration: Administered via p.o.

参考文献：

1.De Bacco F, et al. J Natl Cancer Inst. 2011 Apr, 103(8), 645-661. 2.Torti D, et al. Int J Cancer. 2012, 130(6), 1357-1366.

溶解性：

H2O:<1 mg/mL Ethanol:<1 mg/mL DMSO:35 mg/mL (92.8 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.65 ml	13.25 ml	26.501 ml
5 mM	0.53 ml	2.65 ml	5.3 ml
10 mM	0.265 ml	1.325 ml	2.65 ml
50 mM	0.053 ml	0.265 ml	0.53 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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