货号	规格	价格	上海	北京	珠海	重庆	武汉
S81162-5mg买3赠1	99.80%	￥580.00 S81162-5mg ￥580.00 现货（买3赠1）	1609 >10	-	-	-	-
S81162-10mg买3赠1	99.80%	￥930.00 S81162-10mg ￥930.00 现货（买3赠1）	808 >10	-	-	-	-
S81162-50mg促销	99.80%	￥2470.00 ￥1970.00 S81162-50mg ￥1970.00 现货	170 >10	-	-	-	-
S81162-100mg促销	99.80%	￥3460.00 ￥2760.00 S81162-100mg ￥2760.00 现货	90 >10	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM

靶点：

IC50: 16 nM (Androgen receptor);AndrogenReceptor; GABAReceptor

体内研究：

Apalutamide (ARN-509) exhibits low systemic clearance, high oral bioavailability and long plasma half-life in both mouse and dog, supporting once-daily oral dosing. Consistent with its long terminal-half-life, Apalutamide steady-state plasma-levels increases in repeat-dose studies, resulting in high C24hr levels and low peak:trough ratios (ratio:2.5). Castrate male mice bearing LNCaP/AR xenograft tumors are treated with either Apalutamide at doses of 1, 10 or 30 mg/kg/day. Thirteen of 20 Apalutamide (30 mg/kg/day)-treated animals exhibit >50% reduction in tumor-volume at day 28 versus 3 of 19 MDV3100 (30 mg/kg/day)-treated mice

参考文献：

1. Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15;72(6):1494-503. 2. Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)30133

溶解性：

DMSO : 50 mg/mL (104.73 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.095 ml	10.473 ml	20.945 ml
5 mM	0.419 ml	2.095 ml	4.189 ml
10 mM	0.209 ml	1.047 ml	2.095 ml
50 mM	0.042 ml	0.209 ml	0.419 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置