Rotigotine

99.00%

Rotigotine

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品牌：源叶(MedMol)

产品编号：S81185 一键复制产品信息

CAS号：99755-59-6

分子式：C₁₉H₂₅NOS

分子量：315.47

MDL：MFCD00906149

别名：罗替戈汀;(S)-5,6,7,8-四氢-6-(丙基(2-(2-噻吩基)乙基)氨基)-1-萘酚

货号	规格	价格	上海	北京	珠海	重庆	武汉
S81185-10mg	99.00%	￥300.00 S81185-10mg ￥300.00 现货	5 5	-	-	-	-
S81185-50mg	99.00%	￥1100.00 S81185-50mg ￥1100.00 现货	7 7	-	-	-	-
S81185-100mg	99.00%	￥2000.00 S81185-100mg ￥2000.00 现货	3 3	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research

靶点：

D3 Receptor:0.71 nM (Ki);D2 Receptor:4-15 nM (Ki);D5 Receptor:4-15 nM (Ki);D4 Receptor:4-15 nM (Ki);D1 Receptor:83 nM (Ki);5-HT1A Receptor:30 nM (Ki);5-HT7 Receptor:86 nM (Ki);DopamineReceptor; 5-HTReceptor; AdrenergicReceptor

体内研究：

Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect

参考文献：

1. Wood M, et, al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. 2. Radad K, et, al. Neuroprotective effect of rotigotine against complex I inhibitors, MPP⁺ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86. 3. Bertaina-Anglade V, et, al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24;548(1-3):106-14. 4. Scheller D, et, al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.

溶解性：

DMSO : ≥ 50 mg/mL (158.49 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.17 ml	15.849 ml	31.699 ml
5 mM	0.634 ml	3.17 ml	6.34 ml
10 mM	0.317 ml	1.585 ml	3.17 ml
50 mM	0.063 ml	0.317 ml	0.634 ml