货号	规格	价格	上海	北京	珠海	重庆	武汉
S81186-5mg促销	99.70%	￥98.00 ￥78.00 S81186-5mg ￥78.00 现货	6 6	-	-	-	-
S81186-10mg促销	99.70%	￥180.00 ￥144.00 S81186-10mg ￥144.00 现货	7 7	-	-	-	-
S81186-25mg促销	99.70%	￥360.00 ￥288.00 S81186-25mg ￥288.00 现货	5 5	-	-	-	-
S81186-50mg促销	99.70%	￥560.00 ￥448.00 S81186-50mg ￥448.00 现货	5 5	-	-	-	-
S81186-100mg促销	≥98%	￥1070.00 ￥856.00 S81186-100mg ￥856.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.

靶点：

Apoptosis;HDAC;Apoptosis; HDAC

体内研究：

In SCID mice models, Droxinostat (30 μM)-treated PPC-1 cells results in decreased distant tumor formation than untreated cells.

细胞实验：

PPC-1 cells (1 × 104) are seeded overnight into 96-well flat-bottomed plates in 100 μL of medium containing 2.5% FCS. The next day, Droxinostat is added. CH-11 antibody (100 ng/mL) is then added and the cells are incubated for 24 hours before assessing cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) dye reduction assay.(Only for Reference)

参考文献：

1.Wood TE, et al. Mol Cancer Ther, 2010, 9(1), 246-256. 2.Bijangi-Vishehsaraei K, et al. Mol Cell Biochem, 2010, 342(1-2), 133-142. 3.Mawji IA, et al. J Natl Cancer Inst, 2007, 99(10), 811-822. 4.Schimmer AD, et al. Cancer Res, 2006, 66(4), 2367-2375.

溶解性：

DMSO:46 mg/mL (188.8 mM) Ethanol:46 mg/mL (188.8 mM) H2O:<1 mg/mL

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.104 ml	20.518 ml	41.036 ml
5 mM	0.821 ml	4.104 ml	8.207 ml
10 mM	0.41 ml	2.052 ml	4.104 ml
50 mM	0.082 ml	0.41 ml	0.821 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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