货号	规格	价格	上海	北京	武汉	南京
S81204-5mg	95.1%	￥867.00 S81204-5mg ￥867.00 现货	6 6	-	-	-
S81204-10mg	95.1%	￥1368.50 S81204-10mg ￥1368.50 现货	8 8	-	-	-
S81204-25mg	95.1%	￥2465.00 S81204-25mg ￥2465.00 现货	5 5	-	-	-

产品介绍

GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.

产品描述：

GSK-923295 is a special, allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity, with Ki of 3.2±0.2 nM and 1.6± 0.1 nM for human and canine, respectively.

靶点：

CENP-E:1.6 nM (Ki, Canine CENP-E);Apoptosis; Kinesin

体内研究：

Xenografts of mice treated with GSK-923295 (GSK923295) shows significant tumor growth delay compared to the control arm (NB-EBc1 p<0.0001; NB-1643 p=0.018; NB-1691 p=0.0018)

参考文献：

1. Wood KW, et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5839-44. 2. Mayes PA, et al. Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E (CENP-E) inhibition. Int J Cancer. 2013 Feb 1;132(3):E149-57. 3. Balamuth NJ, et al. Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target. Cancer Res. 2010 Apr 1;70(7):2749-58.

溶解性：

DMSO : 30 mg/mL (50.66 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.689 ml	8.444 ml	16.888 ml
5 mM	0.338 ml	1.689 ml	3.378 ml
10 mM	0.169 ml	0.844 ml	1.689 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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