| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81219-2mg |
99.8% | ￥150.00 | 5 | - | - | - |
|
S81219-10mg |
99.8% | ￥420.00 | 6 | - | - | - |
|
S81219-5mg |
99.8% | ￥428.00 | 6 | - | - | - |
|
S81219-25mg |
99.8% | ￥610.00 | 5 | - | - | - |
|
S81219-50mg |
≥99% | ￥850.00 | 货期：2-3天 | - | - | - |
|
S81219-100mg |
≥99% | ￥1330.00 | 货期：2-3天 | - | - | - |
|
S81219-200mg |
≥99% | ￥2400.00 | 货期：2-3天 | - | - | - |
|
HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).
| 产品描述： | HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5). | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Protein arginine methyltransferase 5;Apoptosis; HistoneMethyltransferase | ||||||||||||||||||||
| 体外研究： | HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Cell Viability Assay Cell Line: MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) Concentration: 1, 5, 10, 25, 50, 100 μM Incubation Time: 24, 48, 72 hours Result: Dose-dependent reduction in cell viability with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively. | ||||||||||||||||||||
| 参考文献： | 1. Tarighat SS, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia. 2016 Apr;30(4):789-99. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京