| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81227-5mg买3赠1 |
99.60% | ￥220.00 |
3 | - | - | - | - |
|
S81227-10mg买3赠1 |
99.60% | ￥370.00 |
9 | - | - | - | - |
|
S81227-25mg买3赠1 |
99.60% | ￥610.00 |
6 | - | - | - | - |
|
S81227-50mg |
99.60% | ￥970.00 |
3 | - | - | - | - |
|
S81227-100mg |
≥99% | ￥1740.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | TBK1:19 nM (IC50, at 0.1 mM ATP);IKKε:160 nM (IC50, at 0.1 mM ATP);ULK2:38 nM (IC50);ULK1:45 nM (IC50);Autophagy;IκB/IKK; Autophagy | ||||||||||||||||||||
| 参考文献： | 1. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. 2. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. 3. Zhu Z, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. 26.37Cancer Discov. 2014 Apr;4(4):452-65. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (215.24 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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