货号	规格	价格	上海	北京	珠海	重庆	武汉
S81271-2mg买3赠1	99.30%	￥160.00 S81271-2mg ￥160.00 现货（买3赠1）	2 2	-	-	-	-
S81271-5mg买3赠1	99.30%	￥280.00 S81271-5mg ￥280.00 现货（买3赠1）	5 5	-	-	-	-
S81271-10mg买3赠1	99.30%	￥336.00 S81271-10mg ￥336.00 现货（买3赠1）	1 1	-	-	-	-
S81271-25mg买3赠1	99.30%	￥640.00 S81271-25mg ￥640.00 现货（买3赠1）	2 0 2	-	-	-	-
S81271-50mg买3赠1	≥99%	￥1160.00 S81271-50mg ￥1160.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S81271-100mg买3赠1	≥99%	￥2240.00 S81271-100mg ￥2240.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 μM

靶点：

Autophagy;Apoptosis;Deubiquitinase;Apoptosis; DUB; Autophagy

体外研究：

Spautin-1 enhances imatinib mesylate (IM)-induced CmL cell apoptosis by reducing the expression of the anti-apoptotic proteins Mcl-1 and Bcl-2. The pro-apoptotic activity of spautin-1 is associated with activation of GSK3β, an important downstream effector of PI3K/AKT. Spautin-1 enhances IM-induced cytotoxicity in CmL cell line K562, decreasing the IC50 from 1 to 0.5 μM. The mechanism of spautin-1 acting on acute pancreatitis is associated with impaired autophagy inhibition

体内研究：

Spautin-1 ameliorates the pathogenesis of acute pancreatitis induced by cerulein or L-arginine. Spautin-1 pretreatment significantly diminishes the elevation of serum amylase and lipase levels, which are indicative of trypsin activity. Increasing levels of serum TNFα caused by cerulein are inhibited in the presence of spautin-1. Spautin-1 treatment can ameliorate the inflammation damage induced by cerulein, such as edema, degeneration, coagulative necrosis and infiltration of inflammatory cells

参考文献：

1. Shao S, et al. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014 May;44(5):1661-1668. 2. Xiao J, et al. Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Mol Med. 2016 Aug 18;22.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.686 ml	18.432 ml	36.864 ml
5 mM	0.737 ml	3.686 ml	7.373 ml
10 mM	0.369 ml	1.843 ml	3.686 ml
50 mM	0.074 ml	0.369 ml	0.737 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=11.4] Yang Xiang et al."Autophagy receptor ZmNBR1 promotes the autophagic degradation of ZmBRI1a and enhances drought tolerance in maize."Journal of Integrative Plant Biology".2024 Apr;:

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