货号	规格	价格	上海	北京	珠海	重庆	武汉
S81294-2mg买3赠1	99.70%	￥238.00 S81294-2mg ￥238.00 现货（买3赠1）	8 8	-	-	-	-
S81294-5mg买3赠1	99.70%	￥314.00 S81294-5mg ￥314.00 现货（买3赠1）	5 5	-	-	-	-
S81294-10mg买3赠1	99.70%	￥595.00 S81294-10mg ￥595.00 现货（买3赠1）	5 5	-	-	-	-
S81294-25mg买3赠1	99.70%	￥1170.00 S81294-25mg ￥1170.00 现货（买3赠1）	5 5	-	-	-	-
S81294-50mg	99.70%	￥1810.00 S81294-50mg ￥1810.00 现货	4 0 4	-	-	-	-
S81294-100mg	≥99%	￥2850.00 S81294-100mg ￥2850.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

GSK343 is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.

靶点：

IC50: 4 nM (EZH2), 240 nM (EZH1);HistoneMethyltransferase; Autophagy

体内研究：

Compare with the controls, GSK343 (5 mg/kg)-treated mice exhibits significantly inhibited tumor growth. The average tumor volume and weight of the GSK343-treated cohort is remarkably reduced. As early as 20 days post-implantation, a significant reduction in tumor growth is observed in the GSK343-treated cohort relative to the control cohort; this difference persisted through the remainder of the study. In addition, compare with the control cohort, the GSK343-treated animals in the xenograft model show a remarkable increase in messenger RNA levels of E-cadherin but a significant decrease in vimentin messenger RNA levels

参考文献：

1. Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. 2. Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42(5):458-64.

溶解性：

DMSO : 15.62 mg/mL (28.84 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.846 ml	9.23 ml	18.461 ml
5 mM	0.369 ml	1.846 ml	3.692 ml
10 mM	0.185 ml	0.923 ml	1.846 ml
50 mM	0.037 ml	0.185 ml	0.369 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=3.7] Yun Zhang et al."MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo."EXPERIMENTAL CELL RESEARCH.2024 Jan;:113913

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