| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81328-2mg促销 |
≥99% | ￥515.00 ￥462.00 |
10 | - | - | - | - |
|
S81328-5mg促销 |
≥99% | ￥1030.00 ￥926.00 |
10 | - | - | - | - |
|
S81328-10mg促销 |
≥99% | ￥1750.00 ￥1570.00 |
10 | - | - | - | - |
|
S81328-25mg促销 |
≥99% | ￥3500.00 ￥3150.00 |
8 | - | - | - | - |
|
S81328-50mg促销 |
≥99% | ￥5660.00 ￥5090.00 |
3 | - | - | - | - |
|
S81328-100mg促销 |
≥99% | ￥8960.00 ￥8060.00 |
4 | - | - | - | - |
|
| 产品描述： | VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC50 of approximate 10 μM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: appr 10 μM (Deubiquitinase);DUB | ||||||||||||||||||||
| 体内研究： | VLX1570 (3 mg/kg) significantly decreases tumor growth in mice bearing KMS-11 multiple myeloma cells. VLX1570 (4.4 mg/kg, i.p.) markedly suppresses tumor growth, without obvious weight loss and other signs of systemic toxicity in the Waldenstrom macroglobulinemia (WM)-bearing mice | ||||||||||||||||||||
| 参考文献： | 1. Wang X, et al. Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15. Chem Biol Drug Des. 2015 Nov;86(5):1036-48. 2. Wang X, et al. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep. 2016 Jun 6;6:26979. 3. Paulus A, et al. Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells. Blood Cancer J. 2016 Nov 4;6(11):e492. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京