货号	规格	价格	上海	北京	珠海	重庆	武汉
S81397-2mg买3赠1	99.80%	￥204.00 S81397-2mg ￥204.00 现货（买3赠1）	8 8	-	-	-	-
S81397-5mg买3赠1	99.80%	￥306.00 S81397-5mg ￥306.00 现货（买3赠1）	6 6	-	-	-	-
S81397-10mg促销	99.80%	￥394.00 ￥315.00 S81397-10mg ￥315.00 现货	6 6	-	-	-	-
S81397-25mg促销	99.80%	￥489.00 ￥390.00 S81397-25mg ￥390.00 现货	5 5	-	-	-	-
S81397-50mg	99.80%	￥646.00 S81397-50mg ￥646.00 现货	4 0 4	-	-	-	-
S81397-100mg	≥98%	￥1200.00 S81397-100mg ￥1200.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

HMN-214, an orally bioavailable prodrug of HMN-176, is an inhibitor of polo-like kinase-1 (plk1), with antitumor activity.

靶点：

PLK1;PLK

体内研究：

HMN-214 (33 mg/kg, p.o.) converts to HMN-176 in rats. HMN-214 has no effect on the conduction velocity and the amplitude of action potentials in the aciatic and tibial nerves. HMN-214 (20 mg/kg, p.o.) exhibits antitumor activity in mice. HMN-214 (10, 20 mg/kg, p.o.) decreases MDR1 mRNA expression in nude mice bearing KB- and KB-A.1.-derived tumors

参考文献：

1. Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99. 2. Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9. 3. Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7. 4. Christensen MD, et al. Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression. J Control Release. 2015 Apr 28;204:20-9.

溶解性：

DMSO : 8.33 mg/mL (19.62 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.356 ml	11.779 ml	23.558 ml
5 mM	0.471 ml	2.356 ml	4.712 ml
10 mM	0.236 ml	1.178 ml	2.356 ml
50 mM	0.047 ml	0.236 ml	0.471 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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