货号	规格	价格	上海	北京	珠海	重庆	武汉
S81399-5mg买3赠1	99.90%	￥296.00 S81399-5mg ￥296.00 现货（买3赠1）	6 6	-	-	-	-
S81399-10mg买3赠1	99.90%	￥350.00 S81399-10mg ￥350.00 现货（买3赠1）	5 5	-	-	-	-
S81399-25mg买3赠1	99.90%	￥560.00 S81399-25mg ￥560.00 现货（买3赠1）	3 0 3	-	-	-	-
S81399-50mg买3赠1	≥99%	￥840.00 S81399-50mg ￥840.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S81399-100mg买3赠1	≥99%	￥1340.00 S81399-100mg ￥1340.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S81399-200mg	≥99%	￥2010.00 S81399-200mg ￥2010.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model

靶点：

Ki: 45.1 nM (CA IX) and 4.5 nM (CA XII) EC50: 0.2 μM (exosome);CarbonicAnhydrase

体内研究：

U-104 (19, 38 mg/kg; daily; for 27 days) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg; daily; for 5 days) inhibits metastases formation in the 4T1 experimental metastasis mice model. U-104 (38 mg/kg; i.p.; from 11 to 27 days) significantly delays primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (50 mg/kg; oral gavage; continuously for 4 days and suspended for 1 day; from 10 to 30 days) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells.

参考文献：

1. Lou Y, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76. 2. Lock FE, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32(44):5210-9. 3. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

溶解性：

DMSO : ≥ 100 mg/mL (323.29 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.233 ml	16.164 ml	32.329 ml
5 mM	0.647 ml	3.233 ml	6.466 ml
10 mM	0.323 ml	1.616 ml	3.233 ml
50 mM	0.065 ml	0.323 ml	0.647 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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