| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81411-1mg买3赠1 |
98.60% | ￥50.00 |
8 | - | - | - | - |
|
S81411-2mg买3赠1 |
98.60% | ￥80.00 |
8 | - | - | - | - |
|
S81411-5mg买3赠1 |
98.60% | ￥110.00 |
8 | - | - | - | - |
|
S81411-10mg买3赠1 |
98.60% | ￥190.00 |
6 | - | - | - | - |
|
S81411-25mg买3赠1 |
98.60% | ￥330.00 |
5 | - | - | - | - |
|
S81411-50mg促销 |
98.60% | ￥560.00 ￥448.00 |
5 | - | - | - | - |
|
S81411-100mg促销 |
98.60% | ￥790.00 ￥632.00 |
5 | - | - | - | - |
|
| 产品描述： | IC261 is a selective, ATP-competitive CK1 inhibitor, with IC50s of 1 μM, 1 μM, 16 μM for Ckiδ, Ckiε and Ckiα1, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | CKIδ:1 μM (IC50);CkIα1:16 μM (IC50);Apoptosis; CaseinKinase; CDK | ||||||||||||||||||||
| 体内研究： | IC261 (20.5 mg/kg) inhibits tumor growth of PancTu-2 cells in SCID mice, downregulates several anti-apoptotic proteins, such as CK1δ/∊, KRAS, and IL6 and upregulates p21, ATM, CHEK1 and STAT1 in mice | ||||||||||||||||||||
| 参考文献： | 1. Mashhoon N, et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. 2. Stöter M, et al. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene. 2005 Dec 1;24(54):7964-75. 3. Brockschmidt C, et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008 Jun;57(6):799-806 | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 33 mg/mL (106.00 mM) | ||||||||||||||||||||
| 保存条件： | RT | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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