5-Iodotubercidin

98.10%

5-Iodotubercidin

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品牌：源叶(MedMol)

产品编号：S81442 一键复制产品信息

CAS号：24386-93-4

分子式：C₁₁H₁₃IN₄O₄

分子量：392.15

别名：5-碘代杀结核菌素;4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine;5-Iodotubercidin; 5-IODOTUBERCIDIN; 5-Iodotubericidin;

货号	规格	价格	上海	北京	珠海	重庆	武汉
S81442-2mg	98.10%	￥400.00 S81442-2mg ￥400.00 现货	858 >10	-	-	-	-
S81442-5mg	98.10%	￥600.00 S81442-5mg ￥600.00 现货	349 >10	-	-	-	-
S81442-25mg	98.10%	￥2000.00 S81442-25mg ￥2000.00 现货	76 0 >10	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin

靶点：

IC50: 26 nM (adenosine kinase);AdenosineReceptor

体内研究：

5-Iodotubercidin (1 mL/kg, i.p.) is in agreement with activity observed against bicuculline-induced seizures following local administration of the AKI into the prepiriform cortex

参考文献：

1. Massillon D, et al. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem J. 1994 Apr 1;299 (Pt 1):123-8. 2. Ugarkar BG, et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem. 2000 Jul 27;43(15):2883-93. 3. García-Villafranca J, et al. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol. 2002 Jun 1;63(11):1997-2000. 4. De Antoni A, et al. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012 Oct 15;199(2):269-84. 5. Acharya MM, et al. Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci. 2016 Jun 3;9:42.

溶解性：

DMSO : 25 mg/mL (63.75 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：