| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81453-2mg买3赠1 |
99.90% | ￥170.00 |
4 | - | - | - | - |
|
S81453-5mg买3赠1 |
99.90% | ￥305.00 |
6 | - | - | - | - |
|
S81453-10mg买3赠1 |
99.90% | ￥374.00 |
2 | - | - | - | - |
|
S81453-25mg买3赠1 |
99.90% | ￥630.00 |
6 | - | - | - | - |
|
S81453-50mg买3赠1 |
≥99% | ￥1100.00 |
货期：2-3天 | - | - | - | - |
|
S81453-100mg买3赠1 |
≥99% | ￥1650.00 |
货期：2-3天 | - | - | - | - |
|
S81453-250mg买3赠1 |
≥99% | ￥3500.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Autophagy | ||||||||||||||||||||
| 体外研究： | SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability. Cell Viability Assay Cell Line: MMS1 cells Concentration: 5, 25, 50, 75, 100, 150, 200 μM Incubation Time: 24 hours Result: Showed a dose dependent decline of cell viability. | ||||||||||||||||||||
| 体内研究： | SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg. Animal Model: 14 to 16 weeks male mice (Balb/c) Dosage: 15, 65 mg/kg Administration: Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days) Result: Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg. | ||||||||||||||||||||
| 参考文献： | 1. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7. 2. Nekova TS, et al. Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/Bpreferentially within a protective bone marrow microenvironment. Br J Haematol. 2014 Oct;167(2):272-4. 3. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85. 4. Koukourakis MI, et al. SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy. Invest New Drugs. 2018 Oct;36(5):773-781. 5. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
