货号	规格	价格	上海	北京	珠海	重庆	武汉
S81472-10mg促销	≥98%(HPLC)	￥462.00 ￥416.00 S81472-10mg ￥416.00 现货	1 1	-	-	3	-
S81472-50mg促销	≥98%(HPLC)	￥1570.00 ￥1410.00 S81472-50mg ￥1410.00 现货	4 4	-	-	-	-
S81472-100mg促销	≥98%(HPLC)	￥2500.00 ￥2250.00 S81472-100mg ￥2250.00 现货	4 4	-	-	-	-
S81472-250mg促销	≥98%(HPLC)	￥5000.00 ￥4500.00 S81472-250mg ￥4500.00 现货	2 2	-	-	-	-

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产品描述：

Tolimidone is a potent and selective allosteric activator of Lyn kinase with an EC50 of 63 nM.

靶点：

EC50: 63 nM (Lyn kinase);Src

体内研究：

Administration of Tolimidone (MLR-1023) (30 mg/kg i.p.) significantly (p<0.05) lowers blood glucose levels to 148 and 158 mg/dL, 30 and 90 min after administration, respectively. Tolimidone significantly increases adipocyte differentiation and adiponectin production by 3.7- and 19-fold, respectively. Tolimidone elicits a dose-dependent potentiation of the insulin response, with a maximal effect observed with a dose level of 30 mg/kg

参考文献：

1. Saporito MS, et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J Pharmacol Exp Ther. 2012 Jul;342(1):15-22. 2. Ochman AR, et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J Pharmacol Exp Ther. 2012 Jul;342(1):23-32.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.945 ml	24.727 ml	49.454 ml
5 mM	0.989 ml	4.945 ml	9.891 ml
10 mM	0.495 ml	2.473 ml	4.945 ml
50 mM	0.099 ml	0.495 ml	0.989 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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