|
产品描述： (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM. |
|
靶点：
Human Endogenous Metabolite;EstrogenReceptor/ERR; Estrogen/progestogenReceptor; EndogenousMetabolite |
体内研究：
(-)-(S)-Equol inhibits the tumor growth by 43.2% and 28.4% compared to the control on day 33, suggesting that the compound is not overtly toxic |
参考文献：
1. Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9. 2. Lu Z, et al. S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Curr Cancer Drug Targets. 2016;16(5):455-65. 3. Horiuchi H, et al. S-equol nantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo). 2014;60(4):291-6. |
|
溶解性：
DMSO : 100 mg/mL (412.76 mM; Need ultrasonic and warming) |
|
保存条件：
-20℃ |
配置溶液浓度参考：
|
1mg |
5mg |
10mg |
| 1 mM |
4.128 ml |
20.638 ml |
41.276 ml |
| 5 mM |
0.826 ml |
4.128 ml |
8.255 ml |
| 10 mM |
0.413 ml |
2.064 ml |
4.128 ml |
| 50 mM |
0.083 ml |
0.413 ml |
0.826 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京