货号	规格	价格	上海	北京	武汉	南京	购买数量
S81489-100mg	99%	￥120.00 S81489-100mg ￥120.00 现货	2 2	-	-	-
S81489-500mg	99%	￥224.00 S81489-500mg ￥224.00 现货	6 6	-	-	-

产品介绍

Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

产品描述：

Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

靶点：

Glucokinase;Microtubule Associated;Parasite;Glucokinase; MicrotubuleAssociated; Parasite

体内研究：

Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and

参考文献：

1.Dewa Y, et al. Arch Toxicol,2009, 83(5), 503-511. 2.Dewa Y, et al. Arch Toxicol,2011, 85(2), 155-162. 3.El-Makawy A, et al. Reprod Nutr Dev,2006, 46(2), 139-156. 4.Gokbulut C, et al. Vet Parasitol,2007, 148(3-4), 279-287. 5.Gleizes C, et al. Biochem Pharmacol,1991, 41(12), 1813-1820.

溶解性：

Ethanol:<1 mg/mL H2O:<1 mg/mL DMSO:10 mg/mL (31.71 mM)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.171 ml	15.855 ml	31.711 ml
5 mM	0.634 ml	3.171 ml	6.342 ml
10 mM	0.317 ml	1.586 ml	3.171 ml
50 mM	0.063 ml	0.317 ml	0.634 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

Oxfendazole