货号	规格	价格	上海	北京	珠海	重庆	武汉
S81492-10mg买3赠1	≥98.0%	￥140.00 S81492-10mg ￥140.00 现货（买3赠1）	4 4	-	-	-	-
S81492-50mg买3赠1	≥98.0%	￥285.00 S81492-50mg ￥285.00 现货（买3赠1）	3 3	-	-	-	-
S81492-250mg	≥98.0%	￥750.00 S81492-250mg ￥750.00 现货	3 3	-	-	-	-
S81492-1g	≥98.0%	￥1910.00 S81492-1g ￥1910.00 2-3天	0 0 货期：2-3天	-	-	-	-

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产品描述：

PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.

靶点：

p53;Apoptosis; Others; Ferroptosis; Autophagy

体内研究：

PRIMA-1 (Prima-1) is a p53-modulating agent. 150 or 300 ppm PRIMA-1 significantly suppresses (P<0.0001) lung adenocarcinoma formation by 56% and 62%, respectively, after 17 weeks and 39% and 56%, respectively, after 34 weeks. Administration of 150 or 300 ppm PRIMA-1 significantly suppresses NNK-induced total lung adenocarcinoma formation by 57% or 62% (P<0.0001), respectively, after 17 weeks of exposure and by 39% or 56% (P<0.0001), respectively, after 34 weeks of exposure. As with administration of the lower (50 ppm) dose of CP-31398, administration of the lower (150 ppm) dose of PRIMA-1also slightly increases the number of NNK-induced lung adenomas

参考文献：

1. Cui B, et al. PRIMA-1, a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. J Clin Endocrinol Metab. 2014 Jun;99(6):E962-70. 2. Zhang Z, et al. Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Apr 8. 3. Rao CV, et al. Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia. 2013 Sep;15(9):1018-27.

溶解性：

Soluble in DMSO、H2O

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	5.399 ml	26.995 ml	53.99 ml
5 mM	1.08 ml	5.399 ml	10.798 ml
10 mM	0.54 ml	2.699 ml	5.399 ml
50 mM	0.108 ml	0.54 ml	1.08 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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