| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81495-2mg |
99.2% | ￥180.00 | 10 | - | - | - |
|
S81495-5mg |
99.2% | ￥245.00 | 6 | - | - | - |
|
S81495-10mg |
99.2% | ￥440.00 | 7 | - | - | - |
|
S81495-25mg |
99.2% | ￥840.00 | 7 | - | - | - |
|
S81495-50mg |
99.2% | ￥1400.00 | 4 | - | - | - |
|
S81495-100mg |
≥97% | ￥1900.00 | 货期：2-3天 | - | - | - |
|
S81495-200mg |
≥97% | ￥3500.00 | 货期：2-3天 | - | - | - |
|
Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively
| 产品描述： | Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | pKi: 8.1 (p38α), 7.6 (p38β);p38MAPK; Autophagy | ||||||||||||||||||||
| 体内研究： | In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β) | ||||||||||||||||||||
| 参考文献： | 1. Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70. 2. Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8. | ||||||||||||||||||||
| 溶解性： | Ethanol : 33.33 mg/mL (86.92 mM; Need ultrasonic) DMSO : 27.5 mg/mL (71.72 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京