货号	规格	价格	上海	北京	珠海	重庆	武汉
S81502-1mg买3赠1	99.80%	￥590.00 S81502-1mg ￥590.00 现货（买3赠1）	1 1	-	-	-	-
S81502-2mg买3赠1	99.80%	￥830.00 S81502-2mg ￥830.00 现货（买3赠1）	3 3	-	-	-	-
S81502-5mg买3赠1	99.80%	￥1050.00 S81502-5mg ￥1050.00 现货（买3赠1）	1 1	-	-	-	-
S81502-10mg	≥98%	￥1570.00 S81502-10mg ￥1570.00 2-3天	0 货期：2-3天	-	-	-	-
S81502-25mg	≥98%	￥3100.00 S81502-25mg ￥3100.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC50 of 5 nM; also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M and EGFRL861Q.

靶点：

EGFR:5 nM (IC50);EGFRL858R;EGFRL858R/T790M;EGFRT790M;EGFRL861Q;EGFR

体内研究：

Icotinib exhibits potent dose-dependent antitumor effects in nude mice carrying a variety of human tumor-derived xenografts. The drug is well tolerated at doses up to 120 mg/kg/day in mice without mortality or significant body weight loss during the treatment. Icotinib inhibits tumor growth at a rate of 25.2%, 45.6% and 51.5% in the A431 cell line groups; 3.4%, 25.9% and 31.0% in the A549 cell line groups; 49.4%, 52.6% and 67.4% in the H460 cell line groups, and 30.3%, 36.4% and 46.5% in the HCT8 cell line groups, at 30, 60 and 120 mg/kg/dose, respectively

参考文献：

1. Tan F, et al. Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. Lung Cancer. 2012 May;76(2):177-82.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.555 ml	12.774 ml	25.548 ml
5 mM	0.511 ml	2.555 ml	5.11 ml
10 mM	0.255 ml	1.277 ml	2.555 ml
50 mM	0.051 ml	0.255 ml	0.511 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=7.59] Jie Xu et al."Erythrocyte membrane camouflaged siRNA/chemodrugs nanoassemblies for cancer combination therapy."Biomaterials Science.2022 Oct;:

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置