| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81521-2mg |
99.9% | ￥90.00 | 10 | - | - | - |
|
S81521-5mg |
99.9% | ￥150.00 | 10 | - | - | - |
|
S81521-10mg |
99.9% | ￥200.00 | >10 | - | - | - |
|
S81521-50mg |
99.9% | ￥560.00 | 10 | - | - | - |
|
S81521-100mg |
99.9% | ￥1000.00 | >10 | - | - | - |
|
S81521-200mg |
99.9% | ￥1650.00 | >10 | - | - | - |
|
S81521-500mg |
99.9% | ￥3200.00 | >10 | - | - | - |
|
Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.
| 产品描述： | Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | 5-HT2A Receptor:8.73 (pIC50);5-HT2A Receptor:9.3 (pKi) | ||||||||||||||||||||
| 体内研究： | Pimavanserin hemitartrate attenuates head-twitch behavior (3 mg/kg p.o.), and prepulse inhibition deficits (1-10 mg/kg s.c.) induced by the 5-HT2A receptor agonist in rats and reduces the hyperactivity induced in mice by the N-methyl-D-aspartate receptor noncompetitive antagonist, consistent with a 5-HT 2A receptor mechanism of action in vivo and antipsychotic-like efficacy. Pimavanserin hemitartrate demonstrates 42.6% oral bioavailability in rats | ||||||||||||||||||||
| 参考文献： | 1. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP- 103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 75 mg/mL (149.23 mM) H2O : 50 mg/mL (99.48 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | RT | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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