| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81543-5mg买3赠1 |
99.60% | ￥320.00 |
5 | - | - | - | - |
|
S81543-10mg买3赠1 |
99.60% | ￥600.00 |
5 | - | - | - | - |
|
S81543-50mg买3赠1 |
99.60% | ￥1600.00 |
7 | - | - | - | - |
|
S81543-250mg买3赠1 |
99.60% | ￥3200.00 |
2 | - | - | - | - |
|
| 产品描述： | WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3. | ||||||||||||||||||||
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| 靶点： | JAK2;STAT3;Apoptosis; JAK; STAT | ||||||||||||||||||||
| 体内研究： | WP1066 (30 mg/kg, o.g.) exerts an additive effect to CTX inhibition of the p-STAT3 pathway within the tumor microenvironment | ||||||||||||||||||||
| 参考文献： | 1. Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796. 2. Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131(1), 8-17 3. Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67(23), 11291-11299. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 44 mg/mL (123.52 mM) Ethanol : 16.67 mg/mL (46.80 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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