货号	规格	价格	上海	北京	珠海	重庆	武汉
S81546-10mg买3赠1	99.40%	￥400.00 S81546-10mg ￥400.00 现货（买3赠1）	10 10	-	-	-	-
S81546-25mg买3赠1	99.40%	￥650.00 S81546-25mg ￥650.00 现货（买3赠1）	5 5	-	-	-	-
S81546-50mg买3赠1	99.40%	￥950.00 S81546-50mg ￥950.00 现货（买3赠1）	5 5	-	-	-	-
S81546-100mg促销	99.40%	￥1400.00 ￥1120.00 S81546-100mg ￥1120.00 现货	3 3	-	-	-	-

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产品描述：

INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.

靶点：

NOD;NOD-like Receptor (NLR);NOD-likeReceptor(NLR); NOD

体内研究：

INF39 (p.o.) reduces systemic and colonic inflammation in rats treated with 2,4- dinitrobenzene sulfonic acid. In inflamed rats, INF39 (12.5/25/50 mg/ kg) markedly increases body weight. DNBS causes a significant increment of spleen weight (+39.3%). This increase is markedly reduced by administration of INF39 (+2.2, +4.3 and +4.8% at 12.5, 25, 50 mg/kg, respectively). The inhibition of NLRP3 inflammasome complex with INF39 can dose-dependently attenuate the decrease in colonic length (?19, ?13 and ?8% at 12.5, 25, 50 mg/kg, respectively). Rats treated with INF39 shows a significant reduction of macroscopic damage score (4.7 at 12.5 mg/kg, 3.1 at 25 mg/kg, and 2.8 at 50 mg/kg).

细胞实验：

Human THP-1 cells were exposed to INF39 (0.1?100 μM, 72 h), and then cell viability was evaluated by the MTT assay.

动物实验：

Animal Models: Male Sprague?Dawley rats. Solvent: olive oil. Dosages: 12.5,25.0,50.0 mg/kg/day,p.o.

参考文献：

1.Cocco M, et al. J Med Chem. 2017, 60(9):3656-3671.

溶解性：

DMSO:10 mM

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.451 ml	22.254 ml	44.508 ml
5 mM	0.89 ml	4.451 ml	8.902 ml
10 mM	0.445 ml	2.225 ml	4.451 ml
50 mM	0.089 ml	0.445 ml	0.89 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=6.543] Wang Yue et al."Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression."Oxid Med Cell Longev. 2021;2021:8419415

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