| 产品描述： | P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 4.2 μM. |
| 靶点： |
EC50: 4.2 μM (USP7) |
| 体内研究： |
In animal tumor model studies, P005091 is well tolerated, inhibits tumor growth, and prolongs survival. Combining P005091 with lenalidomide, HDAC inhibitor SAHA, or dexamethasone triggers synergistic anti-MM activity |
| 参考文献： |
1. Chauhan D, et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell. 2012 Sep 11;22(3):345-58. |
| 溶解性： |
1-Methyl-2-pyrrolidinone : 100 mg/mL (287.17 mM; Need ultrasonic) DMSO : 25 mg/mL (71.79 mM; Need ultrasonic) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.872 ml |
14.359 ml |
28.717 ml |
| 5 mM |
0.574 ml |
2.872 ml |
5.743 ml |
| 10 mM |
0.287 ml |
1.436 ml |
2.872 ml |
| 50 mM |
0.057 ml |
0.287 ml |
0.574 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京