货号	规格	价格	上海	北京	珠海	重庆	武汉
S81553-5mg促销	99.40%	￥230.00 ￥184.00 S81553-5mg ￥184.00 现货	4 4	-	-	-	-
S81553-10mg促销	99.40%	￥350.00 ￥280.00 S81553-10mg ￥280.00 现货	6 6	-	-	-	-
S81553-25mg促销	99.40%	￥730.00 ￥656.00 S81553-25mg ￥656.00 现货	5 5	-	-	-	-
S81553-100mg	≥98%	￥1850.00 S81553-100mg ￥1850.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

MK-8745 is an aurora A kinase inhibitor with an IC50 of 0.6 nM.

靶点：

Aurora A:0.6 nM (IC50);Apoptosis; AuroraKinase

体外研究：

MK-8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK-8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. 1 μM of MK-8745 exposure for 24 h induces cell cycle arrest in all NHL cells, with variable degrees of G2/M arrest. Z138C cells are highly sensitive to MK-8745 (1 μ M) treatment and induces an approximate 5.5-fold increase in the G2/M phase cell population by 96 h. MK-8745 treatment inhibits phosphorylation of Aurora-A in Granta 519 and Z138C cells, while Akata and JVM2 has no effect. MK-8745 specifically inhibits Aurora-A specific function. MK-8745 treatment leads to apoptotic cell death.

参考文献：

1. Jayasree S Nair et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell Cycle. 2012 Feb 15;11(4):807-17. 2. Aparajita Chowdhury et al. A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines. Leuk Lymphoma, 2012 Mar, 53(3):462-71.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.315 ml	11.576 ml	23.153 ml
5 mM	0.463 ml	2.315 ml	4.631 ml
10 mM	0.232 ml	1.158 ml	2.315 ml
50 mM	0.046 ml	0.232 ml	0.463 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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