| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81557-1mg买3赠1 |
99.10% | ￥185.00 |
9 | - | - | - | - |
|
S81557-5mg买3赠1 |
99.10% | ￥370.00 |
5 | - | - | - | - |
|
S81557-10mg买3赠1 |
99.10% | ￥602.00 |
6 | - | - | - | - |
|
S81557-25mg促销 |
99.10% | ￥1120.00 ￥896.00 |
6 | - | - | - | - |
|
S81557-50mg促销 |
≥98% | ￥1870.00 ￥1490.00 |
货期：2-3天 | - | - | - | - |
|
S81557-100mg促销 |
≥98% | ￥3000.00 ￥2400.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | PFI-4 (compound 11) is a potent and highly selective BRPF1 Bromodomain (BRPF1B) inhibitor, with an IC50 of 172 nM. PFI-4 can be used to explore the functional mechanisms of the HBO1/BRPF1 complex and to study bone loss and osteolytic malignant bone lesions | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 3.517 μM (BRPF2), >10 μM (BRD4 (1)), 0.172 μM (BRPF1B), >10 μM (TRIM24);EpigeneticReaderDomain | ||||||||||||||||||||
| 体外研究： | PFI-4 (1.25 µM; 7 or 11 days) inhibits differentiation of human osteoclasts. Cell Viability Assay Cell Line: Osteoclasts Concentration: 1.25 µM Incubation Time: 7 or 11 days Result: Significantly reduces MMP9 secretion in osteoclasts. | ||||||||||||||||||||
| 参考文献： | 1. Meier JC, et al. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. 2. Demont EH, et al. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. (2014) ACS Med Chem Lett. 5(11):1190-1195. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京