| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81560-1mg买3赠1 |
97.80% | ￥296.00 |
9 | - | - | - | - |
|
S81560-5mg买3赠1 |
97.80% | ￥510.00 |
8 | - | - | - | - |
|
S81560-10mg买3赠1 |
97.80% | ￥935.00 |
6 | - | - | - | - |
|
S81560-25mg促销 |
97.80% | ￥2040.00 ￥1630.00 |
6 | - | - | - | - |
|
S81560-50mg促销 |
≥96% | ￥2530.00 ￥2020.00 |
货期：2-3天 | - | - | - | - |
|
S81560-100mg促销 |
≥96% | ￥4420.00 ￥3530.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | CGI-1746 is a potent and highly selective inhibitor of the Btk with IC50 of 1.9 nM. | ||||||||||||||||||||
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| 靶点： | IC50: 1.9 nM (Btk);BTK; Autophagy | ||||||||||||||||||||
| 体内研究： | CGI1746 abrogates B cell-dependent arthritis. CGI1746 treatment (100 mg/kg, s.c, twice-daily dosing) results in significant inhibition (97%) of overall clinical arthritis scores. CGI1746 treatment substantially reduces TNFα, IL-1β and IL-6, as well as MCP1 and MIP-1α on both the mRNA and protein level in the passive anti-collagen II antibody-induced arthritis (CAIA) model. CGI1746 shows comparable efficacy to TNFα blockade and significantly reduces clinical scores, as well as joint inflammation, in mice or rats with established arthritis | ||||||||||||||||||||
| 参考文献： | 1. Di Paolo, Julie A. et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nature Chemical Biology (2011), 7(1), 41-50 2. Kokabee L, et al. Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol Ther. 2015;16(11):1604-15 | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 50 mg/mL (86.25 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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