AdipoRon

97.08%

AdipoRon

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品牌：源叶(MedMol)

产品编号：S81566 一键复制产品信息

CAS号：924416-43-3

分子式：C₂₇H₂₈N₂O₃

分子量：428.52

货号	规格	价格	上海	北京	珠海	重庆	武汉
S81566-5mg促销	97.08%	￥216.00 ￥162.00 S81566-5mg ￥162.00 现货	4 4	-	-	-	-
S81566-25mg促销	97.08%	￥720.00 ￥540.00 S81566-25mg ￥540.00 现货	2 1 2	1	-	-	-
S81566-100mg促销	97.08%	￥2160.00 ￥1620.00 S81566-100mg ￥1620.00 现货	5 5	-	-	-	-
S81566-200mg促销	97.08%	￥3750.00 ￥2812.00 S81566-200mg ￥2812.00 现货	5 5	-	-	-	-

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产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.

靶点：

Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2);Adiponectinreceptor

体内研究：

AdipoRon (50 mg/kg, i.v.) cuases significant phosphorylation of AMPK in skeletal muscle and liver of wild-type mice but not Adipor1−/− Adipor2−/− double-knockout mice. AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice, and prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg). Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice

参考文献：

1. Okada-Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. 2. Wang Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Aug 9;93:123-131. 3. Zhang Y, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82. 4. Hong K, et al. Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action. Microcirculation. 2016 Apr;23(3):207-20.

溶解性：

DMSO : 62.5 mg/mL (145.85 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.334 ml	11.668 ml	23.336 ml
5 mM	0.467 ml	2.334 ml	4.667 ml
10 mM	0.233 ml	1.167 ml	2.334 ml
50 mM	0.047 ml	0.233 ml	0.467 ml