货号	规格	价格	上海	北京	珠海	重庆	武汉
S81612-5mg	≥99%	￥820.00 S81612-5mg ￥820.00 3-5天	0 货期：3-5天	-	-	-	-
S81612-10mg	≥99%	￥1320.00 S81612-10mg ￥1320.00 3-5天	0 货期：3-5天	-	-	-	-
S81612-50mg	≥99%	￥4620.00 S81612-50mg ￥4620.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TZ9 is a selective Rad6 inhibitor. TZ9 inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis, and inhibits the proliferation and migration of metastatic human breast cancer cells

靶点：

E1/E2/E3 Enzyme;Apoptosis;Apoptosis; E1/E2/E3Enzyme

体外研究：

TZ9 (Rad6B SMI #9) (0.5-100 µM; 72 h) inhibits MDA-MB-231 cell proliferation and migration. TZ9 (0.1-5 µM; 24-72 h) delays cell-cycle progression in MDA-MB-231 cells. TZ9 (5 µM; 8-48 h) induces apoptosis in MDA-MB-231 cells. TZ9 (0.5, 1, 2.5, 5 µM; 24 h) inhibits H2A ubiquitination and downregulates levels of PCNA and β-catenin protein in MDA-MB-231 cells. Cell Proliferation Assay Cell Line: MDA-MB-231 cells Concentration: 0.5-100 µM Incubation Time: 72 h Result: Inhibited MDA-MB-231 cell proliferation with IC50 ~6µM. Apoptosis Analysis Cell Line: MDA-MB-231 cells Concentration: 5 µM Incubation Time: 8-48 h Result: Induced cells apoptosis. Cell Cycle Analysis Cell Line: MDA-MB-231 cells Concentration: 0.1-5 µM Incubation Time: 24-72 h Result: Increased the proportion of G2-M-arrested cells by 2-fold and was accompanied by a proportional decrease in S-phase cells when at 24 h.Significantly increased the percentage of cells with cytoplasmic/nuclear cyclin B1 staining. Western Blot Analysis Cell Line: MDA-MB-231 cells Concentration: 0.5, 1, 2.5, 5 µM Incubation Time: 24 h Result: Inhibited H2A ubiquitination, decreased PCNA and β-catenin protein levels.

参考文献：

1. Sanders MA, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Mol Cancer Ther. 2013 Apr;12(4):373-83.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.73 ml	13.649 ml	27.298 ml
5 mM	0.546 ml	2.73 ml	5.46 ml
10 mM	0.273 ml	1.365 ml	2.73 ml
50 mM	0.055 ml	0.273 ml	0.546 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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