货号	规格	价格	上海	北京	珠海	重庆	武汉
S81643-1mg买3赠1	99.50%	￥325.00 S81643-1mg ￥325.00 现货（买3赠1）	9 9	-	-	-	-
S81643-2mg买3赠1	99.50%	￥465.00 S81643-2mg ￥465.00 现货（买3赠1）	9 9	-	-	-	-
S81643-5mg买3赠1	99.50%	￥625.00 S81643-5mg ￥625.00 现货（买3赠1）	7 7	-	-	-	-
S81643-10mg促销	99.50%	￥1030.00 ￥824.00 S81643-10mg ￥824.00 现货	6 6	-	-	-	-
S81643-25mg促销	99.50%	￥2350.00 ￥1880.00 S81643-25mg ￥1880.00 现货	5 5	-	-	-	-

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产品描述：

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27

靶点：

HSP70:4.6 μM (EC50, HeLa cells);HSP

体外研究：

ML346 is an activator of Hsp70, with an EC50 of 4600 nM in HeLa cells. ML346 (10 μM) restores proteostasis, restores CFTR-mediated iodide conductance, and enhances the correct folding of proteins expressed in two different cellular compartments. ML346 (Compound F1) induces multiple responses and strongly induces Hsp70, the oxidative stress response genes (HO1 and GCLM), and a 2.5-fold upregulation of BiP in WT MEF cells. ML346 (0.5-25 μM) exhibits cytoprotective effects in cells after a 35 min severe heat shock, and also causes a two-fold protection from H2O2-induced apoptosis

体内研究：

ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity

参考文献：

1. Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 17. 2. Calamini B, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.673 ml	18.365 ml	36.73 ml
5 mM	0.735 ml	3.673 ml	7.346 ml
10 mM	0.367 ml	1.837 ml	3.673 ml
50 mM	0.073 ml	0.367 ml	0.735 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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