| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81686-2mg买3赠1 |
98.20% | ￥258.00 |
4 | - | - | - | - |
|
S81686-5mg买3赠1 |
98.20% | ￥346.00 |
4 | - | - | - | - |
|
S81686-10mg买3赠1 |
98.20% | ￥612.00 |
3 | - | - | - | - |
|
S81686-25mg买3赠1 |
98.20% | ￥1290.00 |
8 | - | - | - | - |
|
S81686-50mg买3赠1 |
98.20% | ￥2380.00 |
4 | - | - | - | - |
|
S81686-100mg买3赠1 |
≥98% | ￥3740.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | S0859 is a selective, high-affinity generic Na+/HCO3- transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM). | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | NBC;Others | ||||||||||||||||||||
| 参考文献： | 1. Larsen AM, Krogsgaard-Larsen N, Lauritzen G, et al. Gram-scale solution-phase synthesis of selective sodium bicarbonate co-transport inhibitor S0859: in vitro efficacy studies in breast cancer cells. ChemMedChem. 2012 Oct;7(10):1808-14. 2. Lauritzen G, Stock CM, Lemaire J, et al. The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Lett. 2012 Apr 28;317(2):172-83. 3. Kumar S, Flacke JP, Kostin S, et al. SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovasc Res. 2011 Feb 1;89(2):392-400. 4. Ch'en FF, Villafuerte FC, Swietach P, et al. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart. Br J Pharmacol. 2008 Mar;153(5):972-82 | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (188.67 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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