货号	规格	价格	上海	北京	珠海	重庆	武汉
S81704-1mg	≥99%	￥345.00 S81704-1mg ￥345.00 3-5天	0 货期：3-5天	-	-	-	-
S81704-5mg	≥99%	￥820.00 S81704-5mg ￥820.00 3-5天	0 货期：3-5天	-	-	-	-
S81704-10mg	≥99%	￥1230.00 S81704-10mg ￥1230.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

KR-33493 is a FAS-associated factor 1 (FAF1) inhibitor and can be used in studies about Parkinson's disease.

靶点：

Fas/FasL

体外研究：

Bodyweight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period.

体内研究：

In Sprague-Dawley (SD) rats, KR-33493(500 and 1000 mg/kg; oral) shows no significant changes including Bodyweight changes, hematology, serum biochemistry, and urinalysis. In dogs, red blood cell count value in males is significantly higher at the 1000 mg/kg/day dose with KR-33493 and is recovered after the end of the administration period

参考文献：

1. Jeong JW, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016 Nov;81:387-396. 2. Zhao F, et al. [Danggui Niantong decoction induces apoptosis by activating Fas/caspase-8 pathway in rheumatoid arthritis fibroblast-like synoviocytes]. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Aug 30;40(8):1119-1126. Chinese.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.172 ml	10.861 ml	21.723 ml
5 mM	0.434 ml	2.172 ml	4.345 ml
10 mM	0.217 ml	1.086 ml	2.172 ml
50 mM	0.043 ml	0.217 ml	0.434 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

计算重置

KR-33494