| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81718-2mg买3赠1 |
98.00% | ￥544.00 |
1 | - | - | - | - |
|
S81718-5mg买3赠1 |
98.00% | ￥1080.00 |
5 | - | - | - | - |
|
S81718-10mg买3赠1 |
98.00% | ￥1560.00 |
5 | - | - | - | - |
|
S81718-25mg买3赠1 |
98.00% | ￥2040.00 |
10 | - | - | - | - |
|
S81718-100mg |
98.00% | ￥5440.00 |
2 | - | - | - | - |
|
| 产品描述： | GK921 is a transglutaminase 2 (TGase) inhibitor with an IC50 of 7.71 μM for human recombinant TGase 2. | ||||||||||||||||||||
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| 靶点： | IC50: 7.71 μM (TGase);Glutaminase | ||||||||||||||||||||
| 体外研究： | GK921 inhibits the TGase 2-induced polymerization of I-κBα and p53 in a dose-dependent manner. The cytotoxicity of GK921 ranged from GI50 of 10-10 to 10-4 M. The average GI50 is 9.05×10-7 M. GK921 rescues p53 levels and consequently induces apoptosis; a concentration-dependent increase in cleaved poly(ADP-ribose) polymerase (c-PARP) and p53 levels is observed | ||||||||||||||||||||
| 体内研究： | A single treatment with GK921 almost completely reduces tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models | ||||||||||||||||||||
| 参考文献： | 1. Ku BM, et al. Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models. J Cancer Res Clin Oncol. 2014 May;140(5):757-67. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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