| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81722-1mg买3赠1 |
≥99% | ￥100.00 |
货期：2-3天 | - | - | - | - |
|
S81722-2mg买3赠1 |
≥99% | ￥180.00 |
货期：2-3天 | - | - | - | - |
|
S81722-5mg买3赠1 |
99.80% | ￥280.00 |
3 | - | - | - | - |
|
S81722-10mg买3赠1 |
99.80% | ￥320.00 |
>10 | - | - | - | - |
|
S81722-25mg买3赠1 |
99.80% | ￥370.00 |
3 | - | - | - | - |
|
S81722-50mg买3赠1 |
99.80% | ￥600.00 |
4 | - | - | - | - |
|
S81722-100mg买3赠1 |
99.80% | ￥1000.00 |
5 | - | - | - | - |
|
| 产品描述： | Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease | ||||||||||||||||||||
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| 靶点： | αLβ2;Integrin | ||||||||||||||||||||
| 体外研究： | Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM | ||||||||||||||||||||
| 体内研究： | Lifitegrast (SAR 1118), has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Lifitegrast (SAR 1118) ophthalmic drops administered thrice daily deliver therapeutic levels of Lifitegrast (SAR 1118) in the retina and can alleviate the retinal complications associated with diabetes | ||||||||||||||||||||
| 参考文献： | 1. Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15. 2. Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402. 3. Rao VR, et al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin(STZ) model of diabetic retinopathy (DR). Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5198-204. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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