货号	规格	价格	上海	北京	珠海	重庆	武汉
S81723-5mg	≥99%	￥260.00 S81723-5mg ￥260.00 现货	10 10	-	-	-	-
S81723-10mg	≥99%	￥370.00 S81723-10mg ￥370.00 现货	10 10	-	-	-	-
S81723-50mg	≥99%	￥1010.00 S81723-50mg ￥1010.00 现货	10 10	-	-	-	-
S81723-100mg	≥99%	￥1680.00 S81723-100mg ￥1680.00 现货	10 10	-	-	-	-
S81723-1g	≥99%	￥9500.00 S81723-1g ￥9500.00 现货	8 8	-	-	-	-

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产品描述：

(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein.(+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.

靶点：

Monoamine Transporter;MonoamineTransporter

参考文献：

1. Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91. 2. Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.15 ml	15.752 ml	31.504 ml
5 mM	0.63 ml	3.15 ml	6.301 ml
10 mM	0.315 ml	1.575 ml	3.15 ml
50 mM	0.063 ml	0.315 ml	0.63 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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