(+)-Tetrabenazine

≥99%

(+)-Tetrabenazine

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品牌：源叶(MedMol)

产品编号：S81723 一键复制产品信息

CAS号：1026016-83-0

分子式：C₁₉H₂₇NO₃

分子量：317.4226

别名：2H-BENZO[A]QUINOLIZIN-2-ONE,1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (3R,11BR)-; 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-;

货号	规格	价格	上海	北京	珠海	重庆	武汉
S81723-5mg	≥99%	￥260.00 S81723-5mg ￥260.00 现货	10 10	-	-	-	-
S81723-10mg	≥99%	￥370.00 S81723-10mg ￥370.00 现货	10 10	-	-	-	-
S81723-50mg	≥99%	￥1010.00 S81723-50mg ￥1010.00 现货	10 10	-	-	-	-
S81723-100mg	≥99%	￥1680.00 S81723-100mg ￥1680.00 现货	10 10	-	-	-	-
S81723-1g	≥99%	￥9500.00 S81723-1g ￥9500.00 现货	8 8	-	-	-	-

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产品描述：

(+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein.(+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.

靶点：

Monoamine Transporter;MonoamineTransporter

参考文献：

1. Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91. 2. Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：