品牌：源叶(MedMol)

产品编号：S81762 一键复制产品信息

CAS号：1033040-23-1

分子式：C₂₅H₂₂N₈O₂

分子量：466.4946

别名：3-{N'-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2-hydroxy-3'-(tetrazol-5-yl)biphenyl; 3-{N'-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hyd

货号	规格	价格	上海	北京	珠海	重庆	武汉
S81762-5mg	≥98%	￥1390.00 S81762-5mg ￥1390.00 3-5天	0 货期：3-5天	-	-	-	-
S81762-10mg	≥98%	￥2190.00 S81762-10mg ￥2190.00 3-5天	0 货期：3-5天	-	-	-	-
S81762-50mg	≥98%	￥7560.00 S81762-50mg ￥7560.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia

靶点：

TPO receptor;Others

体内研究：

The thrombopoietin (TPO) receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes, and can increases platelet counts, decrease bleeding events and reduce the need for adjunctive or rescue treatments. The TPO receptor agonists are well-tolerated, though uncertainty remains regarding the risk of thromboembolism and bone marrow fibrosis

参考文献：

1. Jerome Francis Hayes. Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics. 6 November 2008. WO2008134338A1. 2. Siegal D et al. Thrombopoietin receptor agonists in primary immune thrombocytopenia. et al. Semin Hematol. 2013 Jan;50 Suppl 1:S18-21

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.144 ml	10.718 ml	21.436 ml
5 mM	0.429 ml	2.144 ml	4.287 ml
10 mM	0.214 ml	1.072 ml	2.144 ml
50 mM	0.043 ml	0.214 ml	0.429 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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