品牌：源叶(MedMol)

产品编号：S81785 一键复制产品信息

CAS号：103733-65-9

分子式：C₁₀H₁₁NO₂

分子量：177.20

MDL：MFCD00144038

别名：(R)-(+)-1,2,3,4-四氢异喹啉-3-羧酸;D-1,2,3,4-四氢异喹啉-3-羧酸;1,2,3,4-TETRAHYDROISOQUINOLINE-(3R)-CARBOXYLIC ACID;1,2,3,4-D-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID;3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO;(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid

货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S81785-100mg促销	98%	￥26.00 ￥24.00 S81785-100mg ￥24.00 现货	8 8	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S81785-100mg促销

98%

￥26.00 ￥24.00

产品描述：

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide. IC50 value: Target: Three Tic-containing (Tic = 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) model peptides were synthesized to assess the tendency of this constrained Phe analogue to fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition. The results of the solution conformational analysis, performed by using Fourier transform infrared absorption and 1H nuclear magnetic resonance, indicate that in chloroform the -Aib-D-Tic-Aib-, -(Aib)2-D-Tic-(Aib)2-, and -L-Pro-D-Tic- sequences fold into intramolecularly H-bonded forms to a great extent. An X-ray diffraction analysis on p-BrBz-(Aib)2-DL-Tic-(Aib)2-OMe monohydrate and p-BrBz-L-Pro-D-Tic-NHMe allows us to conclude that, while the pentapeptide methylester forms an incipient (distorted) 3(10)-helix, the dipeptide methylamide adopts a type-II beta-bend conformation. In both cases, the D-Tic side-chain conformation is D, gauche(-). The implications for the use of the Tic residue in designing conformationally restricted analogues of bioactive peptides are briefly discussed.

靶点：

Others

参考文献：

1. Valle G, et al. Constrained phenylalanine analogues. Preferred conformation of the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) residue. Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):222-32.

溶解性：

Soluble in H2O

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	5.643 ml	28.217 ml	56.433 ml
5 mM	1.129 ml	5.643 ml	11.287 ml
10 mM	0.564 ml	2.822 ml	5.643 ml
50 mM	0.113 ml	0.564 ml	1.129 ml

注意：

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参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

(R)-1,2,3,4-四氢-3-异喹啉羧酸

(R)-(+)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)