货号	规格	价格	上海	北京	珠海	重庆	武汉
S81786-5mg促销	≥98%	￥458.00 ￥412.00 S81786-5mg ￥412.00 现货	10 10	-	-	-	-
S81786-10mg促销	≥98%	￥800.00 ￥720.00 S81786-10mg ￥720.00 现货	10 10	-	-	-	-
S81786-25mg促销	≥98%	￥1640.00 ￥1480.00 S81786-25mg ￥1480.00 现货	10 10	3	2	-	-
S81786-50mg促销	≥98%	￥2200.00 ￥1980.00 S81786-50mg ￥1980.00 现货	4 4	-	-	-	-

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产品描述：

MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.

靶点：

GPR119;GPR

体内研究：

To examine whether the observations in GLUTag and the primary intestinal cells has physiological relevance, C57BL/6 mice are treated with the GPR119 agonist MBX-2982 at a dose of 10 mg/kg. Note that in order to examine a direct GPR119 effect, no DPP-IV inhibitor is co-administered in this experiment, but a DPP-IV inhibitor is used to preserve active GLP-1 in the blood samples. The plasma GLP-1 levels from the mice dosed with MBX-2982 are increased without a glucose load, indicating that GPR119-mediated GLP-1 secretion is not dependent on glucose

参考文献：

1. Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep 5;762:430-42. 2. Lan H, et al. Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways. Br J Pharmacol. 2012 Apr;165(8):2799-807. 3. Yang JW, et al. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J. 2016 Jan;30(1):324-35.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.229 ml	11.147 ml	22.295 ml
5 mM	0.446 ml	2.229 ml	4.459 ml
10 mM	0.223 ml	1.115 ml	2.229 ml
50 mM	0.045 ml	0.223 ml	0.446 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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