货号	规格	价格	上海	北京	珠海	重庆	武汉
S81800-1mg	≥98%	￥480.00 S81800-1mg ￥480.00 现货	10 10	-	-	-	-
S81800-5mg	≥98%	￥1600.00 S81800-5mg ￥1600.00 现货	8 8	-	-	-	-
S81800-10mg	≥98%	￥2240.00 S81800-10mg ￥2240.00 现货	6 6	-	-	-	-
S81800-25mg	≥98%	￥4000.00 S81800-25mg ￥4000.00 现货	4 4	-	-	-	-
S81800-50mg	≥98%	￥6000.00 S81800-50mg ￥6000.00 现货	2 2	-	-	-	-

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产品描述：

IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

靶点：

IC50: 216 nM (IRAK-4), 3.801 μM (JNK-1), >10 μM (JNK-2);IRAK; JNK

体外研究：

IRAK inhibitor 1 possesses significant potency in an IRAK-4 enzyme assay but is poorly active against JNK-1 and JNK-2. IRAK-4 is a novel member of the IRAK family with unique functional properties. IRAK-4 is the closest human homolog to Pelle. Endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 can activate NF-κB as well as mitogen-activated protein (MAP) kinase pathways. Most strikingly, and in contrast to the other IRAKs, IRAK-4 depends on its kinase activity to activate NF-κB. In addition, IRAK-4 is able to phosphorylate IRAK-1, and overexpression of dominant-negative IRAK-4 is blocking the IL-1-induced activation and modification of IRAK-1, suggesting a role of IRAK-4 as a central element in the early signal transduction of Toll/IL-1 receptors, upstream of IRAK-1. IRAK-4 shares the domain structure of the other IRAKs and it is able to activate similar signal transduction pathways, namely NF-κB and MAPK pathways. It rapidly and transiently associates with IRAK-1 and TRAF6 in an IL-1-dependent manner but it is not functionally redundant with IRAK-1. IRAK-4 is an active protein kinase and requires its kinase activity to activate NF-κB. IRAK-4 might act upstream of IRAK-1 as an IRAK-1 activator

参考文献：

1. Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. 2. Li S, et al. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.409 ml	17.044 ml	34.087 ml
5 mM	0.682 ml	3.409 ml	6.817 ml
10 mM	0.341 ml	1.704 ml	3.409 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

IRAK抑制剂1

IRAK inhibitor 1

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)