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Senktide,速激肽NK3激动剂

    
≥98%

SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2

源叶(MedMol)
S81857 一键复制产品信息
106128-89-6
C40H55N7O11S
841.97
[SUCCINYL-ASP6,ME-PHE8] SUBSTANCE P;SUCCINYL-(ASP6,N-ME-PHE8)-SUBSTANCE P (6-11);[SUCCINYL-ASP6 N-ME-PHE8]-SUBSTANCE P (6-11) (SENKTIDE);[SUCCINYL-ASP6,N-ME-PHE8]-SUBSTANCE P, FRAGMENT 6-11;SUCCINYL-;SENKTIDE
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S81857-500ug促销
≥98%

¥428.00 ¥385.00

10 - - - -
S81857-1mg促销
≥98%

¥570.00 ¥512.00

10 - - - -
S81857-5mg促销
≥98%

¥1320.00 ¥1180.00

10 - - - -
S81857-10mg促销
≥98%

¥1990.00 ¥1790.00

2 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Senktide is a tachykinin NK3 receptor agonist.
靶点: NK3 receptor;Neurokininreceptor
体内研究: I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F2,30=10.10, P<0.001)
参考文献: 1. Nordquist RE, et al. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. 2. Keegan KD, et al. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitiveneurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.188 ml 5.938 ml 11.877 ml
5 mM 0.238 ml 1.188 ml 2.375 ml
10 mM 0.119 ml 0.594 ml 1.188 ml
50 mM 0.024 ml 0.119 ml 0.238 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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