| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81857-500ug促销 |
≥98% | ￥428.00 ￥385.00 |
10 | - | - | - | - |
|
S81857-1mg促销 |
≥98% | ￥570.00 ￥512.00 |
10 | - | - | - | - |
|
S81857-5mg促销 |
≥98% | ￥1320.00 ￥1180.00 |
10 | - | - | - | - |
|
S81857-10mg促销 |
≥98% | ￥1990.00 ￥1790.00 |
2 | - | - | - | - |
|
| 产品描述： | Senktide is a tachykinin NK3 receptor agonist. | ||||||||||||||||||||
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| 靶点： | NK3 receptor;Neurokininreceptor | ||||||||||||||||||||
| 体内研究： | I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F2,30=10.10, P<0.001) | ||||||||||||||||||||
| 参考文献： | 1. Nordquist RE, et al. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. 2. Keegan KD, et al. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitiveneurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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