货号	规格	价格	上海	北京	珠海	重庆	武汉
S81866-1mg促销	≥97%	￥3840.00 ￥1000.00 S81866-1mg ￥1000.00 2-4周	0 货期：2-4周	-	-	-	-
S81866-5mg促销	≥97%	￥9600.00 ￥2400.00 S81866-5mg ￥2400.00 2-4周	0 货期：2-4周	-	-	-	-
S81866-10mg促销	≥97%	￥18000.00 ￥4200.00 S81866-10mg ￥4200.00 2-4周	0 货期：2-4周	-	-	-	-

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产品描述：

SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats

靶点：

Drug Metabolite;Others

体内研究：

SMND-309 (2.5-10 mg/kg; oral intragastric; once a day; for 4 weeks; male Sprague-Dawley rats) treatment ameliorates liver function and decreases the elevation of serum hyaluronic acid, laminin, procollagen type III levels and hydroxyproline content in liver tissue. SMND-309 also decreases the elevation in the malondialdehyde level and restored the decrease in superoxide dismutase and glutathione peroxidase activities. SMND-309 treatment reduces the liver damage and the liver fibrosis grade. SMND-309 treatment powerfully down-regulated the expression of connective tissue growth factor (CTGF) in serum and liver

参考文献：

1. Hou J, Tian J, Jiang W, Gao Y, Fu F. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Eur J Pharmacol. 2011 Jan 10;650(1):390-5. 2. Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J. Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23. 3. Wang Y, Zhang J, Han M, et al. SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. Pharm Biol. 2016;54(10):1982-1990.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.791 ml	13.955 ml	27.91 ml
5 mM	0.558 ml	2.791 ml	5.582 ml
10 mM	0.279 ml	1.395 ml	2.791 ml
50 mM	0.056 ml	0.279 ml	0.558 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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