| 产品描述: | GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion. |
| 靶点: |
GCGR |
| 体内研究: |
GLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM |
| 参考文献: |
1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). 2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. |
| 溶解性: |
Soluble in H2O |
| 保存条件: |
-20℃ |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
0.298 ml |
1.49 ml |
2.98 ml |
| 5 mM |
0.06 ml |
0.298 ml |
0.596 ml |
| 10 mM |
0.03 ml |
0.149 ml |
0.298 ml |
| 50 mM |
0.006 ml |
0.03 ml |
0.06 ml |
|
| 注意: |
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