| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81919-5mg |
≥98% | ￥630.00 |
货期：3-5天 | - | - | - | - |
|
S81919-10mg |
≥98% | ￥1090.00 |
货期：3-5天 | - | - | - | - |
|
S81919-25mg |
≥98% | ￥2190.00 |
货期：3-5天 | - | - | - | - |
|
S81919-50mg |
≥98% | ￥3510.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells);Apoptosis | ||||||||||||||||||||
| 体外研究： | G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively | ||||||||||||||||||||
| 参考文献： | 1. Aleo E, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO、THF、Acetone | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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