| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81981-1mg促销 |
≥98% | ￥750.00 ￥590.00 |
10 | - | - | - | - |
|
S81981-5mg促销 |
≥98% | ￥1900.00 ￥1510.00 |
10 | - | - | - | - |
|
S81981-10mg促销 |
≥98% | ￥2900.00 ￥2310.00 |
4 | - | - | - | - |
|
S81981-25mg促销 |
≥98% | ￥5400.00 ￥4310.00 |
3 | - | - | - | - |
|
S81981-50mg促销 |
≥98% | ￥7600.00 ￥6070.00 |
2 | - | - | - | - |
|
S81981-100mg促销 |
≥98% | ￥9700.00 ￥7750.00 |
2 | - | - | - | - |
|
| 产品描述： | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | ETA:3.4 nM (IC50);ETA:6.7 (pA2);ETB:987 nM (IC50);ETB:5.5 (pA2) | ||||||||||||||||||||
| 体内研究： | Aprocitentan (ACT-132577) has a volume of distribution greater than the plasma volume and a longer half-life than its parent compound in the rat. In rat plasma, the mean recovery of Aprocitentan (ACT-132577) ranges from 82.6% to 90.6%, matrix effect of Aprocitentan (ACT-132577) in rat plasma ranges from 101.4% to 115.2% | ||||||||||||||||||||
| 参考文献： | 1. Iglarz M, et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45. 2. Zhang J, et al. Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry. Int J Clin Exp Med. 2015 Oct 15;8(10):18420-6 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京